Modafinil is a wakefulness promoting agent approved for medical use in the US. It is indicated for adult patients with excessive sleepiness that is associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD).1 Modafinil along with its analogues are also currently being investigated for fatigue, substance addictions, psychiatric disorders, and neurological health benefits. Modafinil was approved as a medication in 1998. After more than 20 years Modafinil may be more popular and prevalent than ever. It appears you cannot listen to a podcast or read a popular article without the mention of Modafinil or one of its prodrugs or analogues. Even though it is a prescription medication it can be easily ordered via the “Clearnet” from international sources. Its prodrug, adrafinil, quite often pops its head into OTC supplements. Its analogues CRL-40,940 AKA Flmodafinil and its prodrug, CRL-40,941 AKA Fladrafinil are commonly available as research chemicals or nootropic powders. The more obscure drug, Modafiendz is the N-methylated derivative of Flmodafinil. It can be found on recreational drug oriented, research chemical sites.