Methyl-Dihydrorubrosterone
MDHR™ (Methyl-Dihydrorubrosterone) is a novel steroidal compound available exclusively from ALRI as Pro Anabol. I believe it is 17-methylated Dihydrorubrosterone which is a naturally occurring plant sterol that has been isolated in Silene otites.
The most interesting and exciting thing about this compound is that it contains a 17-hydroxyl group which is necessary for androgen receptor binding. It also contains a 3-hydroxyl group which can be converted via 3beta-Hydroxysteroid dehydrogenase (3b-HSD) into a 3-Keto group, which is also necessary for androgen binding. There is also a ketone at the 6 position which may cause the steroid to exhibit some aromatase inhibition; as seen with the drug exemestane and 6-OXO or androstenetrione which was previously sold as a supplement. However, I would guess that the aromatase inhibiting activity would be mild as exemestane derivatives are 3-8 times less potent aromatase inhibitors when there is a hydroxyl group at the 17 position.
The 17-hydroxyl group on MDHR is protected from liver destruction by the addition of a methyl group, known as 17-alpha alkylation.
ALRI claims that there is zero liver toxicity. However, if this compound is in fact 17-alpha alkylated I can only assume there would be some liver toxicity.
isomerdesign.com (shown below) lists this compound as having a 17-methoxy group. If that is the case the 17-methoxy group would decrease androgen activity and increase progestin activity.